2020-04-08 15:11 from wizard of aahz
Vioxx. That's about all you need to think about. Pain medication.
Worked great. Caused strokes and heart attacks.
Every doctor I talked to said that pulling Vioxx from the market was stupid.
It was a media driven sensation. Many took it themselves for their aches and pains.
I took it for a brief period. It was a wonder drug.
Annals of Internal Medicine has some choice words:
"In the desperate search to find effective treatments for coronavirus disease 2019 (COVID-19), 2 generic drugs, used largely by rheumatologists and dermatologists to treat immune-mediated diseases, have entered the spotlight. The antimalarials hydroxychloroquine (HCQ) and chloroquine (CQ) have demonstrated antiviral activity against severe acute respiratory syndromebcoronavirus 2 (SARSbCoV-2) in vitro and in small, poorly controlled or uncontrolled clinical studies (1b3). Normally, such research would be deemed hypothesis-generating at best. A tweet by President Trump on 21 March 2020 claiming that the combination of HCQ and azithromycin bha[s] a real chance to be one of the biggest game changers in the history of medicineb accelerated a worldwide run on the drugs, with pharmacies reporting shortages within 24 hours."
Title: No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection
My niece had her baby, they allow one support person in the room (her husband).
The hardest part was getting someone to take care of the two older children. Grandma was going to do it but they didn't want her to travel. She had a neighbor watch her other kids.
And there you go. There is now no conclusive evidence either way, because the loudest voices are now pro or anti HCQ based on whether they are pro or anti Trump.
"Science is God until it conflicts with your personal prejudices, preconceived notions and financial incentives."
Undoubtedly there are already clinical trials underway, evaluating the efficacy of HCQ for treating the chinavirus. It is also true however, that we probably do not have time to wait for them to complete in the typical time frame, and we're going to need to rely on initial indications more than usual. This is why it will be good if a mountain of anecdotal evidence emerges quickly.
As for me, I'm siding with the pro-HCQ crowd because Bill Gates is on the other side.
A study of 81 patients in Brazil was halted early for safety reasons after Covid-19 patients taking a higher dose of chloroquine developed irregular heart rates that raised the risk of a potentially fatal heart arrhythmia.
France reported 43 cases of heart incidents linked to treating coronavirus patients with hydroxychloroquine.
Personally, I believe the HCQ probably provides lots of benefits for Covid-19. But it also provides lots of risks. A true case of informed buyer beware.
Give it to try to save someone - sure. But it's not a miracle drug.
what I'm reading is that many NYC hospitals are giving HCQ experimentally to large numbers of patients. some doctors believe it may help a little if given early. nobody believes it's a game-changer.
"So we know that poisonous fish tank cleaner that is not hydroxychloroquine can be lethal if consumed, and now we know that another chemical that also is not hydroxychloroquine may cause irregular heartbeats at high doses. The science is settled."
As for the Brazilian study, all references I can find to it seem to point back to a NYT article, which seems to have a political rather than medical agenda, and also doesn't indicate whether the 11 fatalities were caused by the medication or if they simply succumbed to the virus anyway.
So we still don't know, and that's kind of the point. I'm not concluding that this specific drug is definitely going to be effective, but I'm not giving up hope either.
Subject: Skip this message if you are triggered by conspiracy theories.
...and by "conspiracy theories" I mean that the following is 100% Objectively True (tm) unless someone can change my mind.
Here's what I'm thinking at this point:
1. China manufactured the virus in the Wuhan biolab, using the nearby wet market as a convenient release vector.
2. China already has the vaccine, and has already administered it to ranking members of the CCP.
3. 2 million domestic fatalities is, to them, a small price to pay to knock down the rest of the world.
Can you imagine the kind of panic that would be going on if the pandemic had occurred in 2012, when many people "knew" that it was the end of the world because of the Mayan calendar?
there is at least one other antiviral agent that shows far more promise... statistically significant data showing an ability to reduce viral load in one study, although unfortunately there is not enough data to show that this actually translates to clinical outcomes
I'd like to believe that clinical trials are 100% safe from being influenced by non-medical interests, but knowing how the world works colors me skeptical.
It's frustrating and scary and a bit annoying because the one thing we know for sure is that we don't have the full picture. I don't believe everything I hear, but when I hear something even remotely plausible I like to immerse myself in it, try it on for size and see how it feels. So far, the idea that China knows more than they're telling us still "feels" plausible.
I guess this was inevitable. The first federal criminal charges have been filed in connection with chloroquine hucksterism:
Lots of things are possible, if not "plausible", but if we have absolutely no evidence for any of them, what do we have